Sulphasalazine Induced Hepatotoxicity, A Risk factor of Meconium Aspiration Syndrome in neonates: A Case Study

[...]several components of meconium, especially fat-soluble (free fatty acids, cholesterol, and triglycerides), and water soluble (containing bilirubin, bile acids, enzymes, etc.) ones impair lung function. Meconium is also a source of proinflammatory mediators such as interleukins (IL-1, IL 6, and IL 8), tumor necrosis factors. [...]it may induce inflammation either directly or indirectly through the stimulation of oxidative bursts in neutrophils and alveolar macrophages and may injure the lung parenchyma or lead to vascular leakage causing toxic pneumonitis and hemorrhagic pulmonary edema [16]. Methods: The criteria used for diagnosing meconium aspiration syndrome were: * Presence of meconium stained amniotic fluid. * Tachypnea, retractions, grunting or other abnormal signs on physical examination consistent with pulmonary disease (i.e. onset of respiratory distress within 24 hours of life). * Need for supplemental oxygen or ventilator support. * A compatible chest radiograph (Abnormal chest roentgenograms consistent with aspiration pneumonitis). Nath GDR et al, Study of clinical profile of meconium aspiration syndrome in relation to gestational age and birth weight and their immediate outcome at Narayana Medical College Hospital, Nellore, India International Journal of Contemporary Pediatrics, 2017 Nov;4(6):2142-2150 8.