A Commercially Available and User‐Friendly Catalyst for Hydroamination Reactions under Technical Conditions

A Commercially Available and User‐Friendly Catalyst for Hydroamination Reactions under Technical Conditions

The activity of a simple, commercially available copper salt, [Cu(NCMe)4](BF4) in intramolecular hydroamination reactions of alkynes and allenes is presented. Reactions were successfully carried out in technical acetonitrile in the presence of air. While attempts of alkene hydroamination failed, thi...

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Veröffentlicht in:European journal of organic chemistry 2019-08, Vol.2019 (29), p.4725-4730
Hauptverfasser: Zelenay, Benjamin, Munton, Peter, Tian, Xiaojie, Díez‐González, Silvia
Format: Artikel
Sprache:eng
Schlagworte:
Acetonitrile
Alkynes
Allenes
Catalysis
Catalysts
Copper
Heterocycles
Hydroamination
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Zusammenfassung:The activity of a simple, commercially available copper salt, [Cu(NCMe)4](BF4) in intramolecular hydroamination reactions of alkynes and allenes is presented. Reactions were successfully carried out in technical acetonitrile in the presence of air. While attempts of alkene hydroamination failed, this catalyst was also found active in intermolecular aza‐Michael reactions. A simple yet performing copper‐based catalytic system for intramolecular hydroaminations and intermolecular conjugate additions is reported.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.201900701