Chemical Property and Antibacterial Activity of Metronidazole-decorated Ti through Adhesive Dopamine
In order to present a novel metronidazole-decorated Ti implanted with antibacterial activity through adhesive dopamine, and prepare metronidazole-decorated Ti, Ti substrates were pre-modified with dopamine (DA) coating, and metronidazole was subsequently immobilized onto the surface of DA-modified T...
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| Veröffentlicht in: | Journal of Wuhan University of Technology. Materials science edition 2019-08, Vol.34 (4), p.968-972 |
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| container_title | Journal of Wuhan University of Technology. Materials science edition |
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| creator | Fu, Dongjie Lu, Yi Gao, Shaohuai Peng, Youjian Duan, Haiying |
| description | In order to present a novel metronidazole-decorated Ti implanted with antibacterial activity through adhesive dopamine, and prepare metronidazole-decorated Ti, Ti substrates were pre-modified with dopamine (DA) coating, and metronidazole was subsequently immobilized onto the surface of DA-modified Ti substrates. The prepared MET-decorated Ti interfaces were prepared for surface characterization tests: contacting angle measurements, scanning electron microscope, ATR-FTIR spectroscopy and
in vitro
anti-biofilm formation assay. Statistical tests were performed using by SPSS16.0. Contacting angle measurement, scanning electron microscopy, and ATR-FTIR spectroscopy confIrmed the successful presence of MET grafted on the Ti surface. In addition, the MET-decorated Ti induced good
in vitro
antibacterial activity toward Escherichia coli and Streptococcus mutans,Gram-negative and Gram-positive bacteria, respectively. The modified Ti substrate with enhanced antibacterial activity holds a great potential as implanting material for applications in dental and bone graft substitutes. |
| doi_str_mv | 10.1007/s11595-019-2145-4 |
| format | Article |
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in vitro
anti-biofilm formation assay. Statistical tests were performed using by SPSS16.0. Contacting angle measurement, scanning electron microscopy, and ATR-FTIR spectroscopy confIrmed the successful presence of MET grafted on the Ti surface. In addition, the MET-decorated Ti induced good
in vitro
antibacterial activity toward Escherichia coli and Streptococcus mutans,Gram-negative and Gram-positive bacteria, respectively. The modified Ti substrate with enhanced antibacterial activity holds a great potential as implanting material for applications in dental and bone graft substitutes.</description><identifier>ISSN: 1000-2413</identifier><identifier>EISSN: 1993-0437</identifier><identifier>DOI: 10.1007/s11595-019-2145-4</identifier><language>eng</language><publisher>Wuhan: Wuhan University of Technology</publisher><subject>Biomaterials ; Chemistry and Materials Science ; Decoration ; Dental materials ; Dopamine ; E coli ; Electron microscopes ; Fourier transforms ; Grafting ; Gram-positive bacteria ; Infrared spectroscopy ; Materials Science ; Organic chemistry ; Scanning electron microscopy ; Spectrum analysis ; Statistical tests ; Substitute bone ; Substrates ; Surface properties</subject><ispartof>Journal of Wuhan University of Technology. Materials science edition, 2019-08, Vol.34 (4), p.968-972</ispartof><rights>Wuhan University of Technology and Springer-Verlag GmbH Germany, Part of Springer Nature 2019</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-258efb6b05646d30c9cc2bd9c4260cc7fb35e7758b489f8ede5b7960291c5c1e3</citedby><cites>FETCH-LOGICAL-c316t-258efb6b05646d30c9cc2bd9c4260cc7fb35e7758b489f8ede5b7960291c5c1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11595-019-2145-4$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11595-019-2145-4$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27926,27927,41490,42559,51321</link.rule.ids></links><search><creatorcontrib>Fu, Dongjie</creatorcontrib><creatorcontrib>Lu, Yi</creatorcontrib><creatorcontrib>Gao, Shaohuai</creatorcontrib><creatorcontrib>Peng, Youjian</creatorcontrib><creatorcontrib>Duan, Haiying</creatorcontrib><title>Chemical Property and Antibacterial Activity of Metronidazole-decorated Ti through Adhesive Dopamine</title><title>Journal of Wuhan University of Technology. Materials science edition</title><addtitle>J. Wuhan Univ. Technol.-Mat. Sci. Edit</addtitle><description>In order to present a novel metronidazole-decorated Ti implanted with antibacterial activity through adhesive dopamine, and prepare metronidazole-decorated Ti, Ti substrates were pre-modified with dopamine (DA) coating, and metronidazole was subsequently immobilized onto the surface of DA-modified Ti substrates. The prepared MET-decorated Ti interfaces were prepared for surface characterization tests: contacting angle measurements, scanning electron microscope, ATR-FTIR spectroscopy and
in vitro
anti-biofilm formation assay. Statistical tests were performed using by SPSS16.0. Contacting angle measurement, scanning electron microscopy, and ATR-FTIR spectroscopy confIrmed the successful presence of MET grafted on the Ti surface. In addition, the MET-decorated Ti induced good
in vitro
antibacterial activity toward Escherichia coli and Streptococcus mutans,Gram-negative and Gram-positive bacteria, respectively. The modified Ti substrate with enhanced antibacterial activity holds a great potential as implanting material for applications in dental and bone graft substitutes.</description><subject>Biomaterials</subject><subject>Chemistry and Materials Science</subject><subject>Decoration</subject><subject>Dental materials</subject><subject>Dopamine</subject><subject>E coli</subject><subject>Electron microscopes</subject><subject>Fourier transforms</subject><subject>Grafting</subject><subject>Gram-positive bacteria</subject><subject>Infrared spectroscopy</subject><subject>Materials Science</subject><subject>Organic chemistry</subject><subject>Scanning electron microscopy</subject><subject>Spectrum analysis</subject><subject>Statistical tests</subject><subject>Substitute bone</subject><subject>Substrates</subject><subject>Surface properties</subject><issn>1000-2413</issn><issn>1993-0437</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kMtKw0AUhoMoWKsP4C7genTuySxDvUJFF3U9JDMnzZQ2E2emBX16UyK4cnV--C8Hviy7JviWYFzcRUKEEggThSjhAvGTbEaUYghzVpyOGmOMKCfsPLuIcYMxx0zKWWYXHeycqbf5e_ADhPSV173Nqz65pjYJghutyiR3cKPl2_wVUvC9s_W33wKyYHyoE9h85fLUBb9fd3llO4juAPm9H-qd6-EyO2vrbYSr3zvPPh4fVotntHx7ellUS2QYkQlRUULbyAYLyaVl2ChjaGOV4VRiY4q2YQKKQpQNL1VbggXRFEpiqogRhgCbZzfT7hD85x5i0hu_D_34UlMqS8Z5WagxRaaUCT7GAK0egtvV4UsTrI8w9QRTjzD1EabmY4dOnThm-zWEv-X_Sz8I3nhB</recordid><startdate>20190801</startdate><enddate>20190801</enddate><creator>Fu, Dongjie</creator><creator>Lu, Yi</creator><creator>Gao, Shaohuai</creator><creator>Peng, Youjian</creator><creator>Duan, Haiying</creator><general>Wuhan University of Technology</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20190801</creationdate><title>Chemical Property and Antibacterial Activity of Metronidazole-decorated Ti through Adhesive Dopamine</title><author>Fu, Dongjie ; Lu, Yi ; Gao, Shaohuai ; Peng, Youjian ; Duan, Haiying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-258efb6b05646d30c9cc2bd9c4260cc7fb35e7758b489f8ede5b7960291c5c1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biomaterials</topic><topic>Chemistry and Materials Science</topic><topic>Decoration</topic><topic>Dental materials</topic><topic>Dopamine</topic><topic>E coli</topic><topic>Electron microscopes</topic><topic>Fourier transforms</topic><topic>Grafting</topic><topic>Gram-positive bacteria</topic><topic>Infrared spectroscopy</topic><topic>Materials Science</topic><topic>Organic chemistry</topic><topic>Scanning electron microscopy</topic><topic>Spectrum analysis</topic><topic>Statistical tests</topic><topic>Substitute bone</topic><topic>Substrates</topic><topic>Surface properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fu, Dongjie</creatorcontrib><creatorcontrib>Lu, Yi</creatorcontrib><creatorcontrib>Gao, Shaohuai</creatorcontrib><creatorcontrib>Peng, Youjian</creatorcontrib><creatorcontrib>Duan, Haiying</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of Wuhan University of Technology. Materials science edition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fu, Dongjie</au><au>Lu, Yi</au><au>Gao, Shaohuai</au><au>Peng, Youjian</au><au>Duan, Haiying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemical Property and Antibacterial Activity of Metronidazole-decorated Ti through Adhesive Dopamine</atitle><jtitle>Journal of Wuhan University of Technology. Materials science edition</jtitle><stitle>J. Wuhan Univ. Technol.-Mat. Sci. Edit</stitle><date>2019-08-01</date><risdate>2019</risdate><volume>34</volume><issue>4</issue><spage>968</spage><epage>972</epage><pages>968-972</pages><issn>1000-2413</issn><eissn>1993-0437</eissn><abstract>In order to present a novel metronidazole-decorated Ti implanted with antibacterial activity through adhesive dopamine, and prepare metronidazole-decorated Ti, Ti substrates were pre-modified with dopamine (DA) coating, and metronidazole was subsequently immobilized onto the surface of DA-modified Ti substrates. The prepared MET-decorated Ti interfaces were prepared for surface characterization tests: contacting angle measurements, scanning electron microscope, ATR-FTIR spectroscopy and
in vitro
anti-biofilm formation assay. Statistical tests were performed using by SPSS16.0. Contacting angle measurement, scanning electron microscopy, and ATR-FTIR spectroscopy confIrmed the successful presence of MET grafted on the Ti surface. In addition, the MET-decorated Ti induced good
in vitro
antibacterial activity toward Escherichia coli and Streptococcus mutans,Gram-negative and Gram-positive bacteria, respectively. The modified Ti substrate with enhanced antibacterial activity holds a great potential as implanting material for applications in dental and bone graft substitutes.</abstract><cop>Wuhan</cop><pub>Wuhan University of Technology</pub><doi>10.1007/s11595-019-2145-4</doi><tpages>5</tpages></addata></record> |
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| subjects | Biomaterials Chemistry and Materials Science Decoration Dental materials Dopamine E coli Electron microscopes Fourier transforms Grafting Gram-positive bacteria Infrared spectroscopy Materials Science Organic chemistry Scanning electron microscopy Spectrum analysis Statistical tests Substitute bone Substrates Surface properties |
| title | Chemical Property and Antibacterial Activity of Metronidazole-decorated Ti through Adhesive Dopamine |
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