Chemical Property and Antibacterial Activity of Metronidazole-decorated Ti through Adhesive Dopamine
In order to present a novel metronidazole-decorated Ti implanted with antibacterial activity through adhesive dopamine, and prepare metronidazole-decorated Ti, Ti substrates were pre-modified with dopamine (DA) coating, and metronidazole was subsequently immobilized onto the surface of DA-modified T...
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Veröffentlicht in: | Journal of Wuhan University of Technology. Materials science edition 2019-08, Vol.34 (4), p.968-972 |
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Hauptverfasser: | , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | In order to present a novel metronidazole-decorated Ti implanted with antibacterial activity through adhesive dopamine, and prepare metronidazole-decorated Ti, Ti substrates were pre-modified with dopamine (DA) coating, and metronidazole was subsequently immobilized onto the surface of DA-modified Ti substrates. The prepared MET-decorated Ti interfaces were prepared for surface characterization tests: contacting angle measurements, scanning electron microscope, ATR-FTIR spectroscopy and
in vitro
anti-biofilm formation assay. Statistical tests were performed using by SPSS16.0. Contacting angle measurement, scanning electron microscopy, and ATR-FTIR spectroscopy confIrmed the successful presence of MET grafted on the Ti surface. In addition, the MET-decorated Ti induced good
in vitro
antibacterial activity toward Escherichia coli and Streptococcus mutans,Gram-negative and Gram-positive bacteria, respectively. The modified Ti substrate with enhanced antibacterial activity holds a great potential as implanting material for applications in dental and bone graft substitutes. |
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ISSN: | 1000-2413 1993-0437 |
DOI: | 10.1007/s11595-019-2145-4 |