Click inspired synthesis of hexa and octadecavalent peripheral galactosylated glycodendrimers and their possible therapeutic applications

A Cu( i )-catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction (CuAAC) has been utilized for the synthesis of novel glycodendrimers containing a rigid hexapropargyloxy benzene centered core with 6- and 18-peripheral β- d -galactopyranosidic units. Structures of the novel glycodendrimers and intermediates were well elucidated using nuclear magnetic resonance and infrared spectroscopies, matrix assisted laser desorption/ionization mass spectrometry, and size-exclusion chromatography. The therapeutic evaluations of the developed glycodendrimers were investigated and they were found to have good potential as anti-bacterial, anti-biofilm, and anti-tumour agents. Click inspired glycodendrimers comprising a rigid hexapropargyloxy benzene core with peripheral β- d -galactopyranosidic units were developed and evaluated for their therapeutic potential.