Synthesis of 2-Substituted 6-(Polyfluoromethyl)pyrimidine-4-carbaldehyde Acetals

Synthesis of 2-Substituted 6-(Polyfluoromethyl)pyrimidine-4-carbaldehyde Acetals

Heterocyclization of 5,5-difluoro- and 5,5,5-trifluoro-2,4-dioxopentanal dimethyl acetals with amidines in the presence of 4 equiv of triethyl borate afforded 2-substituted 6-(difluoromethyl)- and 6-(trifluoromethyl)pyrimidine-4-carbaldehyde dimethyl acetals in high yields.

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Veröffentlicht in:Russian journal of organic chemistry 2019-06, Vol.55 (6), p.879-882
Hauptverfasser: Belyaev, D. V., Chizhov, D. L., Rusinov, G. L., Charushin, V. N.
Format: Artikel
Sprache:eng
Schlagworte:
Acetals
Chemistry
Chemistry and Materials Science
Dimethyl acetals
Organic Chemistry
Short Communications
Substitutes
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Zusammenfassung:Heterocyclization of 5,5-difluoro- and 5,5,5-trifluoro-2,4-dioxopentanal dimethyl acetals with amidines in the presence of 4 equiv of triethyl borate afforded 2-substituted 6-(difluoromethyl)- and 6-(trifluoromethyl)pyrimidine-4-carbaldehyde dimethyl acetals in high yields.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428019060204