Multi‐Well Sensor Platform Based on a Partially Etched Structure of a Light‐Addressable Potentiometric Sensor

A multi‐well‐structured light‐addressable potentiometric sensor (LAPS) plate is developed for measuring a plurality of sample solutions on a single sensor plate. It is also capable of high‐resolution chemical imaging inside the well structure. It can be applied, for example, to quantification of metabolic activities and imaging of biological samples incubated in the well structure. A minimum pattern size of 20 µm line is visualized and a wider frequency bandwidth of up to 200 kHz for the sensor signal is obtained in the well structure, which will be suitable for recording chemical images at a high‐frame‐rate. A multi‐well‐structured light‐addressable potentiometric sensor (LAPS) plate is developed. With multiple wells on the sensing surface, this sensor is capable of measuring a plurality of sample solutions on a single sensor plate without additional multi‐chamber structures. The application of the sensor includes quantification of metabolic activities and imaging of biological samples incubated in the well structure.