Synthesis of 4,5-disubstituted-1H-1,2,3-triazoles

Two-step procedure, a palladium catalyzed Sonogashira cross-coupling reaction of aroyl chlorides with aryl acetylenes, and 1,3-dipolar cycloaddition of the 1,3-diarylprop-2-yn-1-ones with sodium azide under catalyst free conditions achieved the synthesis of aryl(4-aryl-1 H -1,2,3-triazol-5-yl)methanones in moderate-to-good chemical yields (30–90%). The procedures allowed the synthesis of 4,5-disubstituted-1 H -1,2,3-triazol scaffolds containing electron-neutral, -withdrawing, or -donating groups. Graphic abstract