Combinatorial process and plant design for agile manufacture

The concept of combinatorial process, equipment and plant design is introduced and developed for the specific examples of fluid separations and crystallisation. It is shown that traditional methods of process design may miss options that are identified using the combinatorial approach. New options may lead to novel types of processes and equipment. Application of this methodology is suggested in terms of scanning the multi-dimensional space describing the process, equipment and plant attributes. The new approach is particularly appropriate for the design of agile plants for families of products and where decisions have to be made as how best to re-configure an existing facility to manufacture a new product.