Catalytic Asymmetric Transfer Hydrogenation of Ketones Using [Ru(p-cymene)Cl₂]₂ with Chiral Amino Alcohol Ligands

Catalytic Asymmetric Transfer Hydrogenation of Ketones Using [Ru(p-cymene)Cl₂]₂ with Chiral Amino Alcohol Ligands

Catalytic asymmetric transfer hydrogenation of aromatic alkyl ketones has been investigated using [Ru(p-cymene)Cl₂]₂ and new derivatives of β-amino alcohols synthesized from (S)-(−)-lactic acid and mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (6...

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Veröffentlicht in:Catalysis letters 2010-09, Vol.138 (3-4), p.231-238
Hauptverfasser: Deshpande, Sudhindra H, Kelkar, Ashutosh A, Gonnade, Rajesh G, Shingote, Savita K, Chaudhari, Raghunath V
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Alcohol
Alcohols
Amino alcohol ligand
Asymmetric transfer hydrogenation
Asymmetry
Catalysis
Chemistry
Chemistry and Materials Science
Conversion
Exact sciences and technology
General and physical chemistry
Hydrogenation
Industrial Chemistry/Chemical Engineering
Ketones
Lactic acid
Ligands
Organometallic Chemistry
Physical Chemistry
Ru catalyst
Synthesis
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
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Zusammenfassung:Catalytic asymmetric transfer hydrogenation of aromatic alkyl ketones has been investigated using [Ru(p-cymene)Cl₂]₂ and new derivatives of β-amino alcohols synthesized from (S)-(−)-lactic acid and mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (60-90%) and moderate to good enantioselectivities (40-86%). Graphical Abstract Asymmetric transfer hydrogenation of ketones has been investigated using [Ru(p-cymene)Cl₂]₂ and β-amino alcohols synthesized from (S)-(−)-lactic acid and Mandelic acid as ligands. Chiral secondary alcohols were obtained with good to excellent conversion (60-90%) and moderate to good enantioselectivities (40-86%). [graphic removed]
ISSN:1011-372X
1572-879X
DOI:10.1007/s10562-010-0408-y