Copper(I) Halide for Regioselective Ortho-Halogenation of Directed Arenes

Copper(I) Halide for Regioselective Ortho-Halogenation of Directed Arenes

We describe a copper(I) mediated halogenation via direct C–H functionalization of arenes. The combination of Cu(I)X and (diacetoxyiodo)benzene provides a robust system for halogenation of 2-arylpyridines. High regio- and mono-selectivity was achieved for chlorination, bromination, and iodination of...

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Veröffentlicht in:Catalysis letters 2018-04, Vol.148 (4), p.1067-1072
Hauptverfasser: Perumgani, Pullaiah C., Parvathaneni, Sai Prathima, Surendra Babu, G. V., Srinivas, K., Mandapati, Mohan Rao
Format: Artikel
Sprache:eng
Schlagworte:
Aromatic compounds
Benzene
Bonds (Securities)
Bromination
Catalysis
Chemistry
Chemistry and Materials Science
Copper
Halogenation
Industrial Chemistry/Chemical Engineering
Iodination
Organometallic Chemistry
Physical Chemistry
Selectivity
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Zusammenfassung:We describe a copper(I) mediated halogenation via direct C–H functionalization of arenes. The combination of Cu(I)X and (diacetoxyiodo)benzene provides a robust system for halogenation of 2-arylpyridines. High regio- and mono-selectivity was achieved for chlorination, bromination, and iodination of arene C–H bonds. Graphical Abstract
ISSN:1011-372X
1572-879X
DOI:10.1007/s10562-018-2324-5