APPLICABILITY OF DENTAL PANORAMIC RADIOMORPHOMETRIC AND FRACTAL DIMENSION ANALYSIS IN THE EVALUATION OF ANTIEPILEPTIC DRUG-INDUCED OSTEOPOROSIS

The use of AED leads to altered bone metabolism, such as reduction in bone mineral density (BMD) and inferior levels of 25-hydroxyvitamin D (25OHD), and induced bone loss, causing: increased catabolism of active vitamin D metabolites due to hepatic enzyme induction, direct effects on bone cells, hyperparathyroidism and calcitonin deficiency [2]. According to these results, the mean of FD1, FD2, FD3 and mean-FD value obtained by averaging the FD values of 4 different regions were significantly higher in controls (p=0.027, p=0.001, p=0.032, and p=0.006 respectively) than in patients. [14] In another study conducted in Thailand, the authors revealed that 36% of 123 adult epileptic patients had osteopenia, whereas 4.1% had osteoporosis. 25 (20%) epilepsy patients had vitamin D deficiency, no correlation being found between BMD values and vitamin D status. Phabphal K, Geater A, Leelawattana R, Sathirapunya P, Sattawatcharawanich S, Limapichat K. Prevalence and risk factors of low bone mineral density and 25-hydroxyvitamin D status in young healthy epileptic adult patients in a tropical Asian country taking antiepileptic drug.