Augmented Accumbal Serotonin Levels Decrease the Preference for a Morphine Associated Environment During Withdrawal

Recent studies have found that acute morphine administration increases serotonin (5-HT) transmission within the nucleus accumbens and other forebrain regions. In contrast, 5-HT transmission is depressed during withdrawal from chronic morphine. We show that pharmacological agents that increase brain...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2001-01, Vol.24 (1), p.75-85
Hauptverfasser:	Harris, Glenda C, Aston-Jones, Gary
Format:	Artikel
Sprache:	eng
Schlagworte:	5-HTP, Morphine 5-Hydroxytryptophan - pharmacology Abstinence Addictive behaviors Animals Anxiety Anxiety - drug therapy Anxiety - metabolism Anxiety - physiopathology Biological and medical sciences Conditioning (Psychology) - drug effects Conditioning (Psychology) - physiology Dopamine Drug addictions Drug Administration Schedule Drug withdrawal Environment, Controlled Fluoxetine Fluoxetine - pharmacology Head Movements - drug effects Head Movements - physiology Male Medical sciences Morphine Morphine - pharmacology Morphine Dependence - drug therapy Morphine Dependence - metabolism Morphine Dependence - physiopathology Narcotics Neurons - cytology Neurons - drug effects Neurons - metabolism Nucleus Accumbens - cytology Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Place conditioning Rats Rats, Sprague-Dawley Serotonin Serotonin - metabolism Substance Withdrawal Syndrome - drug therapy Substance Withdrawal Syndrome - metabolism Substance Withdrawal Syndrome - physiopathology Toxicology Withdrawal
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Zusammenfassung:	Recent studies have found that acute morphine administration increases serotonin (5-HT) transmission within the nucleus accumbens and other forebrain regions. In contrast, 5-HT transmission is depressed during withdrawal from chronic morphine. We show that pharmacological agents that increase brain 5-HT levels (fluoxetine or 5-hydoxytryptophan, 5-HTP) abolish the preference of chronically morphine-treated, withdrawn rats for a morphine-associated environment. Similar results were seen when fluoxetine was microinjected into the nucleus accumbens. Conversely, rats given morphine acutely showed an enhanced preference for a morphine-associated environment when pretreated with these agents. Fluoxetine also decreased the heightened anxiety found in morphine withdrawn rats. The results of our study indicate that drugs that augment 5-HT levels may reduce the desire for morphine during withdrawal.
ISSN:	0893-133X 1740-634X
DOI:	10.1016/S0893-133X(00)00184-6