Tyrosine kinase inhibitor levels matter in treating chronic GVHD

Key points We observed a possible concentration effect relationship for nilotinib on resolution of chronic Graft versus Host disease. These data suggest therapeutic drug monitoring might be useful for patients receiving tyrosine kinase inhibitors for chronic GVHD.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2019-07, Vol.54 (7), p.1141-1144
Hauptverfasser:	van der Wagen, Lotte, Janssen, Julie, Raijmakers, Reinier, Petersen, Eefke, de Witte, Moniek, de Jong, Niels, Bellido, Mar, Meijer, Ellen, Bär, Brigitte, Jan Boelens, Jaap, Huitema, Alwin, Kuball, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/1904 631/67/1990 692/699/249/1529 82/16 82/58 Allografts Cell Biology Chronic Disease Correspondence Female Graft vs Host Disease - drug therapy Graft vs Host Disease - etiology Graft-versus-host reaction Hematology Humans Internal Medicine Kinases Male Medicine Medicine & Public Health Netherlands Prospective Studies Protein Kinase Inhibitors - administration & dosage Protein Kinase Inhibitors - adverse effects Public Health Pyrimidines - administration & dosage Pyrimidines - adverse effects Registries Retrospective Studies Rituximab - administration & dosage Rituximab - adverse effects Stem Cell Transplantation Stem Cells Tyrosine Tyrosine kinase inhibitors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Key points We observed a possible concentration effect relationship for nilotinib on resolution of chronic Graft versus Host disease. These data suggest therapeutic drug monitoring might be useful for patients receiving tyrosine kinase inhibitors for chronic GVHD.
ISSN:	0268-3369 1476-5365
DOI:	10.1038/s41409-018-0429-5