Heparin-induced thrombocytopenia and the use of r-hirudin during cardiopulmonary bypass

Heparin-induced thrombocytopenia and the use of r-hirudin during cardiopulmonary bypass

We report the successful use of r-hirudin (lepirudin) for cardiopulmonary bypass in a 67-year-old man who developed heparin-induced thrombocytopenia type II during heparin treatment of an extensive deep venous thrombosis. Lepirudin was monitored by the modified ecarin clotting time in a "mobile...

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Veröffentlicht in:Anaesthesia and intensive care 2005-06, Vol.33 (3), p.388-392
Hauptverfasser: MANIKAPPA, S, BENFIELD, K, GAN, T. E, BUTLER, J, MALAN, E, TRAN, H. A. M, TUCKER, A
Format: Artikel
Sprache:eng
Schlagworte:
Aged
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Cardiopulmonary Bypass
Heparin - adverse effects
Hirudin Therapy
Humans
Male
Medical sciences
Monitoring, Intraoperative - methods
Thrombocytopenia - chemically induced
Thrombocytopenia - classification
Venous Thrombosis - drug therapy
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Zusammenfassung:We report the successful use of r-hirudin (lepirudin) for cardiopulmonary bypass in a 67-year-old man who developed heparin-induced thrombocytopenia type II during heparin treatment of an extensive deep venous thrombosis. Lepirudin was monitored by the modified ecarin clotting time in a "mobile laboratory" set up next to the cardiac theatre, aiming for lepirudin levels of 3.5 to 4.5 microg/ml during bypass.
ISSN:0310-057X
1448-0271
DOI:10.1177/0310057x0503300316