1452-P: Association between Aging and Insulin Resistance and Secretion in a General Nondiabetic Population

1452-P: Association between Aging and Insulin Resistance and Secretion in a General Nondiabetic Population

Objective: Aging is one of the risks for abnormal glucose tolerance or diabetes. Although association between age and, insulin secretion and resistance has been reported in various cross sectional studies, few studies evaluated changes of insulin resistance and secretion along with aging. Research D...

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Veröffentlicht in:Diabetes (New York, N.Y.) N.Y.), 2019-06, Vol.68 (Supplement_1)
Hauptverfasser: FUJITA, TOMOYUKI, DAIMON, MAKOTO, MURAKAMI, HIROSHI, MIZUSHIRI, SATORU, MATSUHASHI, YUKI, OSONOI, SHO, MURABAYASHI, MASAYA, TAKAHASHI, KAZUHISA, NISHIYA, YUKI
Format: Artikel
Sprache:eng
Schlagworte:
Adipose tissue
Aging
Diabetes
Diabetes mellitus
Glucose
Glucose tolerance
Homeostasis
Insulin
Insulin resistance
Insulin secretion
Leptin
Metabolites
Multiple regression analysis
Population studies
Secretion
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Zusammenfassung:Objective: Aging is one of the risks for abnormal glucose tolerance or diabetes. Although association between age and, insulin secretion and resistance has been reported in various cross sectional studies, few studies evaluated changes of insulin resistance and secretion along with aging. Research Design and Methods: Among participants of the population-based Iwaki study of Japanese, those participated consecutively from 2014 to 2017 and were nondiabetic were included in this study (Men/Women: 200/294; Age: 21-90 (54.2 ± 13.5)). The effects of aging on homeostasis model assessment indices for insulin resistance (HOMA-R) and β-cell function (HOMA-β) were examined. Results: During the 3-year periods, HOMA-R significantly increased (p
ISSN:0012-1797
1939-327X
DOI:10.2337/db19-1452-P