527-P: Renal Hemodynamic and RAAS Profiles in Patients with Type 2 Diabetes (T2D) and Heart Failure (HF)

HF is associated with decreased renal blood flow and RAAS activation, which may be aggravated in the presence of T2D. The renal arterial-venous gradient for RAAS markers has not been previously reported in HF patients. Our aim was to characterize renal hemodynamic function and renal arterial-venous gradient for RAAS markers in patients with: (1) HF with T2D, (2) HF without T2D, and (3) controls without HF or T2D. In this post hoc analysis, GFRinulin, ERPFPAH, plasma angiotensin converting enzyme (ACE), ACE2, aldosterone, angiotensinogen, plasma renin activity (PRA) and ACE activity were measured in renal artery and vein samples from 20 HF with T2D, 28 HF without T2D and 24 controls. RAAS inhibitors were used in 90% of HF and 63% of controls. GFR and ERPF were higher in controls vs. HF with and without T2D (p