Acute Reversible Cardiomyopathy and Thromboembolism After Cisplatin and 5-Fluorouracil Chemotherapy: A Case Report

Acute development of cardiomyopathy and occlusive thromboembolic events following cisplatin and 5-fluorouracil (5-FU) is rare but frequently lethal. The authors report the successful management of such an event in a 52-year-old man with squamous cell carcinoma of the soft palate. The possible pathop...

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Veröffentlicht in:	Angiology 2000-10, Vol.51 (10), p.873-878
Hauptverfasser:	Cheriparambil, Kuruvilla Mani, Vasireddy, Hemalatha, Kuruvilla, Anita, Gambarin, Boris, Makan, Majesh, Saul, Barry I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Carcinoma, Squamous Cell - drug therapy Cardiomyopathies - chemically induced Cisplatin - adverse effects Drug toxicity and drugs side effects treatment Fluorouracil - adverse effects Heart Diseases - chemically induced Heart Ventricles - diagnostic imaging Humans Male Medical sciences Middle Aged Palatal Neoplasms - drug therapy Pharmacology. Drug treatments Thromboembolism - chemically induced Toxicity: cardiovascular system Ultrasonography
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Zusammenfassung:	Acute development of cardiomyopathy and occlusive thromboembolic events following cisplatin and 5-fluorouracil (5-FU) is rare but frequently lethal. The authors report the successful management of such an event in a 52-year-old man with squamous cell carcinoma of the soft palate. The possible pathophysiological mechanisms are discussed.
ISSN:	0003-3197 1940-1574
DOI:	10.1177/000331970005101011