Refining the accuracy of validated target identification through coding variant finemapping in type 2 diabetes

We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P

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Veröffentlicht in:	Nature genetics 2018-04, Vol.50 (4), p.559-3
Hauptverfasser:	Mahajan, Anubha, Wessel, Jennifer, Willems, Sara M, Taliun, Daniel, Jensen, Richard A, Zhang, Weihua, Cook, James P, Prins, Bram Peter, Grarup, Niels, Trubetskoy, Vassily Vladimirovich, Kravic, Jasmina, Müller-Nurasyid, Martina, Ligthart, Symen, Gustafsson, Stefan, Steinthorsdottir, Valgerdur, Wuttke, Matthias, Bielak, Lawrence F, Graff, Marielisa, Ahlqvist, Emma, Amin, Najaf, Bertoni, Alain G, Bombieri, Cristina, Brody, Jennifer A, Burtt, Noël P, Eastwood, Sophie V, Gambaro, Giovanni, Hai, Yang, rg-Hansen, Anne Tybjæ, Isomaa, Bo, Jäger, Susanne, Jørgensen, Torben, Kriebel, Jennifer, Kronenberg, Florian, Läll, Kristi, Lee, Jung-Jin, Lehne, Benjamin, Lin, Keng-Hung, Linneberg, Allan, Liu, Ching-Ti, Loh, Marie, Mamakou, Vasiliki, McKean-Cowdin, Roberta, Neville, Matt, Nielsen, Sune F, Ntalla, Ioanna, Schönherr, Sebastian, Small, Kerrin S, Stančáková, Alena, Surendran, Praveen, Thorleifsson, Gudmar, Tönjes, Anke, Witte, Daniel R, Yajnik, Pranav, Yengo, Loïc, Amouyel, Philippe, Boerwinkle, Eric, Collins, Francis S, Dehghan, Abbas, Deloukas, Panos, Ferrières, Jean, Florez, Jose C, Frossard, Philippe, Gudnason, Vilmundur, Harris, Tamara B, Ingelsson, Martin, Kathiresan, Sekar, Kuusisto, Johanna, Langenberg, Claudia, Lindgren, Cecilia M, Mohlke, Karen L, Murray, Alison D, Owen, Katharine R, Rasheed, Asif, Ridker, Paul M, Rosengren, Anders H, Sladek, Rob, Blüher, Matthias, Butterworth, Adam S, Chambers, John Campbell, Danesh, John, van Duijn, Cornelia, Dupuis, Josée, Franco, Oscar H, Han, Bok-Ghee, Hattersley, Andrew T, Kardia, Sharon L R, Karpe, Fredrik, Laakso, Markku, Lind, Lars, Mook-Kanamori, Dennis, Rauramaa, Rainer, Spector, Timothy D, Stumvoll, Michael, Thorsteinsdottir, Unnur, Tuomi, Tiinamaija, Wareham, Nicholas J, Barroso, Inês, Goodarzi, Mark O, Saleheen, Danish, McCarthy, Mark I
Format:	Artikel
Sprache:	eng
Schlagworte:	Body mass index Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Epidemiology Genomes Genomics Genotype & phenotype Haplotypes Identification Inference Quality control Studies Target recognition Therapeutic applications
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Beschreibung
Zusammenfassung:	We aggregated coding variant data for 81,412 type 2 diabetes cases and 370,832 controls of diverse ancestry, identifying 40 coding variant association signals (P
ISSN:	1061-4036 1546-1718
DOI:	10.1038/s41588-018-0084-1