Advances in the Total Synthesis of Biologically Important Marine Macrolides

Advances in the Total Synthesis of Biologically Important Marine Macrolides

The important biological activities of the microtubule-interacting spongistatins/altohyrtins, dicrtyostatin and peluroside A, coupled with supply and the structural complexity of marine macrolides demand that organic chemists keep pushing back the limits of what they can synthesize.

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Veröffentlicht in:Chemical reviews 2005-12, Vol.105 (12), p.4237-4313
Hauptverfasser: Yeung, Kap-Sun, Paterson, Ian
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Chemical synthesis
Cyclization
Macrolides - chemical synthesis
Macrolides - chemistry
Marine biology
Marine Toxins - chemical synthesis
Marine Toxins - chemistry
Molecular Conformation
Organic chemistry
Protein Conformation
Protein Structure, Tertiary
Stereoisomerism
Structure-Activity Relationship
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Zusammenfassung:The important biological activities of the microtubule-interacting spongistatins/altohyrtins, dicrtyostatin and peluroside A, coupled with supply and the structural complexity of marine macrolides demand that organic chemists keep pushing back the limits of what they can synthesize.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr040614c