Engineering Novel Metalloproteins:  Design of Metal-Binding Sites into Native Protein Scaffolds

The protein design process can be divided into two steps: the design of overall scaffold and the design of active sites. Lu et al focus on the creation of metal-binding sites in existing proteins with characteristic scaffolds by de novo design or by the redesign of existing sites.

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Veröffentlicht in:Chemical reviews 2001-10, Vol.101 (10), p.3047-3080
Hauptverfasser: Lu, Yi, Berry, Steven M, Pfister, Thomas D
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Sprache:eng
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