Engineering Novel Metalloproteins: Design of Metal-Binding Sites into Native Protein Scaffolds
The protein design process can be divided into two steps: the design of overall scaffold and the design of active sites. Lu et al focus on the creation of metal-binding sites in existing proteins with characteristic scaffolds by de novo design or by the redesign of existing sites.
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| Veröffentlicht in: | Chemical reviews 2001-10, Vol.101 (10), p.3047-3080 |
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| container_title | Chemical reviews |
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| creator | Lu, Yi Berry, Steven M Pfister, Thomas D |
| description | The protein design process can be divided into two steps: the design of overall scaffold and the design of active sites. Lu et al focus on the creation of metal-binding sites in existing proteins with characteristic scaffolds by de novo design or by the redesign of existing sites. |
| doi_str_mv | 10.1021/cr0000574 |
| format | Article |
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Lu et al focus on the creation of metal-binding sites in existing proteins with characteristic scaffolds by de novo design or by the redesign of existing sites.</description><subject>Amino Acid Sequence</subject><subject>Binding Sites</subject><subject>Chemical reactions</subject><subject>Chemistry</subject><subject>Computer Simulation</subject><subject>Hemeproteins - chemistry</subject><subject>Ligands</subject><subject>Metalloproteins - chemistry</subject><subject>Metals</subject><subject>Metals - chemistry</subject><subject>Metals - metabolism</subject><subject>Models, Molecular</subject><subject>Models, Structural</subject><subject>Molecular Sequence Data</subject><subject>Mutagenesis</subject><subject>Peptide Library</subject><subject>Protein Binding</subject><subject>Protein Conformation</subject><subject>Protein Engineering - methods</subject><subject>Proteins</subject><subject>Sequence Analysis, Protein</subject><subject>Substrate Specificity</subject><issn>0009-2665</issn><issn>1520-6890</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2001</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkM9OwzAMxiMEYmNw4AVQhcSBQyFJ26Tlxp_BkMYY2pC4RWnrTBldC0k3wY0rr8mTkNFpO2AfLNk_-7M-hA4JPiOYkvPMYBcRD7dQm0QU-yxO8DZqu2biU8aiFtqzdrpkIsp3UYsQTjBmtI1kt5zoEsDocuINqgUU3gPUsiiqN1PVoEt78fP17d2A1ZPSq1Qz9a90mS83RroG6-myrryBrPUCvGGz5o0yqVRV5HYf7ShZWDhY1Q56vu2Or3t-__Hu_vqy78uAs9pPKcmVVBJnBMecJJzLFIIkV2GMORCXUUBYilNF8zCnoEIVxDEBRmQUpiELOui4uesef5-DrcW0mpvSSQpKQ8YDHsUOOm2gzFTWGlDizeiZNJ-CYLH0Uqy9dOzR6uA8nUG-IVfmOcBvAG1r-FjPpXkVf3JiPByJYe-JJewlEYnjTxpeZnbz3H_hX00oigo</recordid><startdate>20011001</startdate><enddate>20011001</enddate><creator>Lu, Yi</creator><creator>Berry, Steven M</creator><creator>Pfister, Thomas D</creator><general>American Chemical Society</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20011001</creationdate><title>Engineering Novel Metalloproteins: Design of Metal-Binding Sites into Native Protein Scaffolds</title><author>Lu, Yi ; Berry, Steven M ; Pfister, Thomas D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a376t-b21dfafa0c10871977abe39df4807e1e1e5316b0bf2d4d2ef4f3881e61a54b463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2001</creationdate><topic>Amino Acid Sequence</topic><topic>Binding Sites</topic><topic>Chemical reactions</topic><topic>Chemistry</topic><topic>Computer Simulation</topic><topic>Hemeproteins - chemistry</topic><topic>Ligands</topic><topic>Metalloproteins - chemistry</topic><topic>Metals</topic><topic>Metals - chemistry</topic><topic>Metals - metabolism</topic><topic>Models, Molecular</topic><topic>Models, Structural</topic><topic>Molecular Sequence Data</topic><topic>Mutagenesis</topic><topic>Peptide Library</topic><topic>Protein Binding</topic><topic>Protein Conformation</topic><topic>Protein Engineering - methods</topic><topic>Proteins</topic><topic>Sequence Analysis, Protein</topic><topic>Substrate Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lu, Yi</creatorcontrib><creatorcontrib>Berry, Steven M</creatorcontrib><creatorcontrib>Pfister, Thomas D</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Chemical reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lu, Yi</au><au>Berry, Steven M</au><au>Pfister, Thomas D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Engineering Novel Metalloproteins: Design of Metal-Binding Sites into Native Protein Scaffolds</atitle><jtitle>Chemical reviews</jtitle><addtitle>Chem. 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| fulltext | fulltext |
| identifier | ISSN: 0009-2665 |
| ispartof | Chemical reviews, 2001-10, Vol.101 (10), p.3047-3080 |
| issn | 0009-2665 1520-6890 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Amino Acid Sequence Binding Sites Chemical reactions Chemistry Computer Simulation Hemeproteins - chemistry Ligands Metalloproteins - chemistry Metals Metals - chemistry Metals - metabolism Models, Molecular Models, Structural Molecular Sequence Data Mutagenesis Peptide Library Protein Binding Protein Conformation Protein Engineering - methods Proteins Sequence Analysis, Protein Substrate Specificity |
| title | Engineering Novel Metalloproteins: Design of Metal-Binding Sites into Native Protein Scaffolds |
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