Perspectives on Chemistry and Therapeutic Applications of Locked Nucleic Acid (LNA)

Perspectives on Chemistry and Therapeutic Applications of Locked Nucleic Acid (LNA)

The therapeutic potentials of locked nucleic acid (LNA)-based oligonucleotides are discussed. Special attention is given to the role of such chemicals in silencing or modulating gene expression.

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Bibliographische Detailangaben
Veröffentlicht in:Chemical reviews 2007-11, Vol.107 (11), p.4672-4697
Hauptverfasser: Kaur, Harleen, Babu, B. Ravindra, Maiti, Souvik
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Animals
Biochemistry
Biomedical research
Chemical compounds
Clinical Trials as Topic
Gene expression
Humans
Nucleic Acids - chemistry
Nucleic Acids - therapeutic use
Nucleic Acids - toxicity
Oligonucleotides - chemistry
Oligonucleotides - therapeutic use
Oligonucleotides - toxicity
Oligonucleotides, Antisense - chemistry
Oligonucleotides, Antisense - therapeutic use
Oligonucleotides, Antisense - toxicity
Pharmacology
RNA - drug effects
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Beschreibung
Zusammenfassung:The therapeutic potentials of locked nucleic acid (LNA)-based oligonucleotides are discussed. Special attention is given to the role of such chemicals in silencing or modulating gene expression.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr050266u