Expression of Heart-Type Fatty Acid-Binding Protein in Human Gastric Carcinoma and Its Association with Tumor Aggressiveness, Metastasis and Poor Prognosis

Objective: Fatty acid-binding proteins (FABPs) are involved in lipid metabolism by intracellular transport of long-chain fatty acids. Heart-type (H-) FABP has been reported to inhibit cell growth and induce cell differentiation, but to our knowledge the significance of H-FABP expression in human gas...

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Veröffentlicht in:Pathobiology (Basel) 2004-01, Vol.71 (5), p.267-273
Hauptverfasser: Hashimoto, Takeaki, Kusakabe, Takashi, Sugino, Takashi, Fukuda, Takeaki, Watanabe, Kazuo, Sato, Yukio, Nashimoto, Atsushi, Honma, Keiichi, Kimura, Hideki, Fujii, Hiroshi, Suzuki, Toshimitsu
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Sprache:eng
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Zusammenfassung:Objective: Fatty acid-binding proteins (FABPs) are involved in lipid metabolism by intracellular transport of long-chain fatty acids. Heart-type (H-) FABP has been reported to inhibit cell growth and induce cell differentiation, but to our knowledge the significance of H-FABP expression in human gastric carcinoma has not been elucidated. The aim of the current study was to examine the expression of H-FABP and its relation to clinicopathologic parameters and fatty acid synthase (FAS) status of gastric carcinoma, since gastric cancer shows increased expression of FAS. Methods: Immunohistochemistry with anti-H-FABP antibody was performed in 669 gastric carcinomas and 60 tubular adenomas of the stomach. H-FABP-positive and H-FABP-negative carcinomas were analyzed for their clinicopathologic characteristics and FAS status. Results: None of the adenomas expressed H-FABP, whereas 127 of 669 carcinomas (19.0%) were positive for the protein. H-FABP positivity was associated with the depth of invasion (p < 0.0001), vascular invasion (p < 0.0001), lymph node metastasis (p < 0.0001), hepatic metastasis (p = 0.0011), stage of the carcinoma (p < 0.0001) and FAS status of the carcinoma (p = 0.0476). A higher survival rate was noted in H-FABP-negative cases compared with H-FABP-positive cases (p = 0.0004). Conclusions: A subset of human gastric carcinoma expresses H-FABP and its expression is associated with FAS status, disease progression, tumor aggressiveness and poor patient survival.
ISSN:1015-2008
1423-0291
DOI:10.1159/000080061