In vitro activity of novel derivatives of 1,3-oxazole-4-carboxylate and 1,3-oxazole-4-carbonitrile against human cytomegalovirus

In vitro activity of novel derivatives of 1,3-oxazole-4-carboxylate and 1,3-oxazole-4-carbonitrile against human cytomegalovirus

Ten 5-functionalized derivatives of 1,3-oxazole-4-carboxylate and 1,3-oxazole-4-carbonitrile were synthesized and their antiviral activities against the human cytomegalovirus (HCMV) were evaluated in vitro. Bioassays showed that seven compounds exhibited considerably higher antiviral activity (EC 50...

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Veröffentlicht in:Medicinal chemistry research 2019-08, Vol.28 (8), p.1205-1211
Hauptverfasser: Kachaeva, Maryna V., Pilyo, Stepan G., Hartline, Caroll B., Harden, Emma A., Prichard, Mark N., Zhirnov, Victor V., Brovarets, Volodymyr S.
Format: Artikel
Sprache:eng
Schlagworte:
Antiviral activity
Antiviral agents
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cidofovir
Cytomegalovirus
Derivatives
Drugs
Ganciclovir
Original Research
Oxazole
Pharmacology/Toxicology
Reagents
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Zusammenfassung:Ten 5-functionalized derivatives of 1,3-oxazole-4-carboxylate and 1,3-oxazole-4-carbonitrile were synthesized and their antiviral activities against the human cytomegalovirus (HCMV) were evaluated in vitro. Bioassays showed that seven compounds exhibited considerably higher antiviral activity (EC 50 : 30 µM and SI 50 :
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-019-02365-x