Pd-catalyzed Cyclization of Terminal Alkynes using Diazonaphthoquinones: Synthesis of Naphtho[1,2-b]furans

Pd-catalyzed Cyclization of Terminal Alkynes using Diazonaphthoquinones: Synthesis of Naphtho[1,2-b]furans

Naphtho[1,2-b]furans were synthesized via a Pd-catalyzed reaction of diazonaphthoquinones and terminal alkynes in the presence of CuI and diisopropylamine. This method was then successfully applied to the synthesis of natural product, furomollugin.

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Veröffentlicht in:Chemistry letters 2019-01, Vol.48 (1), p.28-31
Hauptverfasser: Takahashi, Shuhei, Shimooka, Hirokazu, Okauchi, Tatsuo, Kitamura, Mitsuru
Format: Artikel
Sprache:eng
Schlagworte:
Alkynes
Chemical synthesis
Furans
Natural products
Palladium
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Zusammenfassung:Naphtho[1,2-b]furans were synthesized via a Pd-catalyzed reaction of diazonaphthoquinones and terminal alkynes in the presence of CuI and diisopropylamine. This method was then successfully applied to the synthesis of natural product, furomollugin.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.180803