NMR Spectroscopic Characterization and Inclusion Mode of a Cyclodextrin-based Glyco-cluster with Antiphlogistic Ibuprofen Sodium Salt

NMR Spectroscopic Characterization and Inclusion Mode of a Cyclodextrin-based Glyco-cluster with Antiphlogistic Ibuprofen Sodium Salt

Inclusion complex of per-d-mannose-grafted-β-cyclodextrin (Man-CD), synthesized by azide-alkyne “click reaction,” with ibuprofen sodium salt (IBUNa) was investigated by NMR spectroscopy. NMR titration showed its 1:1 stoichiometry and 3.3-fold higher binding constant than that of parent β-cyclodextri...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemistry letters 2018-01, Vol.47 (3), p.276
Hauptverfasser: Han, Bin, Sakairi, Nobuo
Format: Artikel
Sprache:eng ; fre ; ger ; jpn
Schlagworte:
Alkynes
Chemical reactions
Cyclodextrins
Ibuprofen
Mannose
NMR spectroscopy
Nonsteroidal anti-inflammatory drugs
Sodium salts
Stoichiometry
Titration
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Inclusion complex of per-d-mannose-grafted-β-cyclodextrin (Man-CD), synthesized by azide-alkyne “click reaction,” with ibuprofen sodium salt (IBUNa) was investigated by NMR spectroscopy. NMR titration showed its 1:1 stoichiometry and 3.3-fold higher binding constant than that of parent β-cyclodextrin (β-CD). Furthermore, possible orientations of the guest molecules were deduced by 2D NOESY and ROESY experiments.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.171000