Synthesis and Diol-responsiveness of a Boronic Lipid

Synthesis and Diol-responsiveness of a Boronic Lipid

1,2-Dipalmitoryl-sn-glycero-3-(3-boronopropyl-N,N-dimethylaminium) (DPBA), a lipid which specifically binds to diol compounds through the boronic acid moiety, was synthesized. Cryo-TEM observation revealed that DPBA formed unilamellar vesicles in an aqueous environment. Thermotropic phase-transition...

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Veröffentlicht in:Chemistry letters 2017-03, Vol.46 (3), p.293-295
Hauptverfasser: Aikawa, Tatsuo, Nezu, Yusuke, Tsuchiya, Koji, Kondo, Takeshi, Yuasa, Makoto
Format: Artikel
Sprache:eng
Schlagworte:
Aqueous environments
Diols
Lipids
Phase transitions
Transition temperature
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Zusammenfassung:1,2-Dipalmitoryl-sn-glycero-3-(3-boronopropyl-N,N-dimethylaminium) (DPBA), a lipid which specifically binds to diol compounds through the boronic acid moiety, was synthesized. Cryo-TEM observation revealed that DPBA formed unilamellar vesicles in an aqueous environment. Thermotropic phase-transition temperature of DPBA was increased in response to addition of either diols or phosphatidylcholine, indicating that DPBA has both diol responsivity and is characteristic as a reversed-head lipid.
ISSN:0366-7022
1348-0715
DOI:10.1246/cl.161023