Direct C-3 alkylation of coumarins via decarboxylative coupling with carboxylic acids

Direct C-3 alkylation of coumarins via decarboxylative coupling with carboxylic acids

A new method for selective C-3 alkylation of coumarins using carboxylic acids as alkyl sources is reported. This process offers a practical method for the facile construction of 3-alkyl coumarins with a broad substrate scope. The reaction works under metal-free and aqueous media and both cyclic and...

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Veröffentlicht in:New journal of chemistry 2019, Vol.43 (24), p.9328-9332
Hauptverfasser: Jafarpour, Farnaz, Darvishmolla, Masoumeh, Azaddoost, Narges, Mohaghegh, Farid
Format: Artikel
Sprache:eng
Schlagworte:
Aliphatic compounds
Alkylation
Aqueous solutions
Carboxylic acids
Cross coupling
Substrates
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Zusammenfassung:A new method for selective C-3 alkylation of coumarins using carboxylic acids as alkyl sources is reported. This process offers a practical method for the facile construction of 3-alkyl coumarins with a broad substrate scope. The reaction works under metal-free and aqueous media and both cyclic and acyclic aliphatic carboxylic acids participate in this radical C–C cross coupling reaction.
ISSN:1144-0546
1369-9261
DOI:10.1039/C8NJ06410E