A Comparison of Sustained-Release Bupropion and Placebo for Smoking Cessation

Pharmacologic treatments such as nicotine-replacement therapy have been shown to help smokers stop smoking. Using a medication that does not contain nicotine, such as an antidepressant, has intrigued investigators for several reasons. Smokers are more likely to have a history of major depression than nonsmokers, 1 , 2 and nicotine may act as an antidepressant in some smokers. 3 , 4 The development of a depressed affect or depression after smoking cessation may lead to relapse. 5 – 7 Results of clinical trials of antidepressant therapy for smoking cessation have been mixed. The initial experience with doxepin was promising; however, no large trials have been reported. . . .