The Effects of Dietary Protein Restriction and Blood-Pressure Control on the Progression of Chronic Renal Disease

Protein restriction and control of blood pressure delay the progression of renal disease in laboratory animals 1 – 3 . Most studies in humans 4 – 10 have suggested that a restriction of dietary protein is beneficial, especially in patients with advanced renal disease, 4 , 10 but some of these studies were inconclusive because of deficiencies in their design or because changes in renal function were assessed only by measurements of serum creatinine, which may be affected by diet. Furthermore, few previous studies of renal disease have examined the effect on renal function of a reduction in blood pressure to a level below that currently . . .