A Pilot Study of Isotretinoin in the Treatment of Juvenile Chronic Myelogenous Leukemia

Juvenile chronic myelogenous leukemia (CML) is a rare leukemia of infants and young children characterized by a proliferation of myelocytes in peripheral blood and other tissues. A number of clinical 1 – 3 and laboratory 4 – 7 features, including the absence of the Philadelphia chromosome and other...

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Veröffentlicht in:	The New England journal of medicine 1994-12, Vol.331 (25), p.1680-1684
Hauptverfasser:	Castleberry, Robert P, Emanuel, Peter D, Zuckerman, Kenneth S, Cohn, Susan, Strauss, Lewis, Byrd, Rebecca L, Homans, Alan, Chaffee, Sarah, Nitschke, Ruprecht, Gualtieri, Richard J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Antineoplastic agents Biological and medical sciences Bone marrow Bone marrow transplantation Cancer therapies Cell proliferation Chemotherapy Child, Preschool Children Chronic myeloid leukemia Colonies Colony-stimulating factor Drug dosages Female Granulocyte-macrophage colony-stimulating factor Granulocyte-Macrophage Colony-Stimulating Factor - drug effects Granulocytes Hemopoiesis Humans Hypersensitivity Infant Infants Isotretinoin - therapeutic use Leukemia Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukocytosis Macrophages Male Medical sciences Monocytosis Myeloid leukemia Patients Peripheral blood Pharmacology. Drug treatments Pilot Projects Progenitor cells Prospective Studies Retinoic acid Transplantation Transplants & implants
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