A Pilot Study of Isotretinoin in the Treatment of Juvenile Chronic Myelogenous Leukemia

Juvenile chronic myelogenous leukemia (CML) is a rare leukemia of infants and young children characterized by a proliferation of myelocytes in peripheral blood and other tissues. A number of clinical 1 – 3 and laboratory 4 – 7 features, including the absence of the Philadelphia chromosome and other...

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Veröffentlicht in:The New England journal of medicine 1994-12, Vol.331 (25), p.1680-1684
Hauptverfasser: Castleberry, Robert P, Emanuel, Peter D, Zuckerman, Kenneth S, Cohn, Susan, Strauss, Lewis, Byrd, Rebecca L, Homans, Alan, Chaffee, Sarah, Nitschke, Ruprecht, Gualtieri, Richard J
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Sprache:eng
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Zusammenfassung:Juvenile chronic myelogenous leukemia (CML) is a rare leukemia of infants and young children characterized by a proliferation of myelocytes in peripheral blood and other tissues. A number of clinical 1 – 3 and laboratory 4 – 7 features, including the absence of the Philadelphia chromosome and other chromosomal abnormalities and spontaneous proliferation of peripheral-blood leukemic progenitor cells -- granulocyte-macrophage colony-forming units (CFU-GM) -- in vitro, distinguish juvenile CML from the more common adult type of chronic myelogenous leukemia, which is positive for the Philadelphia chromosome. The spontaneous colony growth appears to be related to the selective hypersensitivity of CFU-GM from patients with juvenile . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199412223312503