Autologous Bone Marrow Transplantation as Compared with Salvage Chemotherapy in Relapses of Chemotherapy-Sensitive Non-Hodgkin's Lymphoma

It is generally agreed that patients with intermediate- or high-grade non-Hodgkin's lymphoma who have a relapse after initial therapy have a poor prognosis. 1 , 2 A retrospective study in 1984 from France and England showed a clear relation between the responsiveness of the lymphoma to treatment and the outcome. 3 In 1987, the combination of high-dose chemotherapy and autologous bone marrow transplantation in patients with non-Hodgkin's lymphoma in relapse was considered promising but experimental and appropriate for use only at research centers. 1 The value of that treatment remains an open question, because conventional salvage treatment without autologous bone marrow transplantation can induce . . .