Inhibition of the Platelet Glycoprotein IIb/IIIa Receptor with Tirofiban in Unstable Angina and Non–Q-Wave Myocardial Infarction

Platelet activation and aggregation, with resultant arterial thrombus formation, are pivotal in the pathophysiology of acute coronary syndromes. 1 , 2 The development of inhibitors of fibrinogen binding to the platelet glycoprotein IIb/IIIa receptor has expanded the therapeutic options for treating thrombotic disorders. 3 , 4 The effectiveness of the inhibitor drugs in preventing acute ischemic complications related to abrupt vessel closure after angioplasty has been well documented. 5 – 9 Pilot studies have suggested that blockade of the platelet glycoprotein IIb/IIIa receptor may also be useful in the treatment of patients with unstable angina, whether or not they are also undergoing interventional procedures. 10 – 13 We . . .