Analgesic Nephropathy

To the Editor: To substantiate their thesis on the nephrotoxicity of mixed analgesics, De Broe and Elseviers (Feb. 12 issue) 1 claim that in Belgium the decrease in the frequency of analgesic nephropathy began only in 1992, five years after unspecified legislative measures led to a dramatic decrease in the sales of analgesic mixtures. The complete data (Figure 1), drawn from the same European Dialysis and Transplantation Association registry as that in the reference quoted by De Broe and Elseviers, 2 show a maximal incidence in 1976, so the decrease began much earlier than 1992 and could not be related to the . . .