Nitrous Oxide and 5,10-Methylenetetrahydrofolate Reductase

To the Editor: Regarding the article by Selzer et al. on the adverse effect of nitrous oxide (July 3 issue), 1 I would like to point out that, in 1978, my colleagues and I showed that nitrous oxide inactivated vitamin B 12 in vivo. 2 My colleague John Amess, as a member of the department of the late David Mollin, observed megaloblastic erythropoiesis in a patient who had received nitrous oxide in 1975 after being injured in a train accident at Moorgate Station on the edge of the City of London. We then conducted a prospective trial in which we showed, using . . .