MEDICAL PROGRESS: Renal-Cell Carcinoma
Pathologic cooperativity between renal-cancer cells of the clear-cell type and adjacent vasculature is shown in Panel A. In clear-cell renal-cell carcinoma, hypoxia-inducible factor a (HIF-α) transcription factor accumulates, resulting in the overexpression of proteins that are normally inducible wi...
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| Veröffentlicht in: | The New England journal of medicine 2005-12, Vol.353 (23), p.2477 |
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| creator | Cohen, Herbert T McGovern, Francis J |
| description | Pathologic cooperativity between renal-cancer cells of the clear-cell type and adjacent vasculature is shown in Panel A. In clear-cell renal-cell carcinoma, hypoxia-inducible factor a (HIF-α) transcription factor accumulates, resulting in the overexpression of proteins that are normally inducible with hypoxia, such as transforming growth factor a and β (TGF-α and TGF-β, respectively), vascular endothelial growth factor (VEGF), and platelet-derived growth factor B chain (PDGF-B). |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 2005-12, Vol.353 (23), p.2477 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Cancer Genetics Kidneys Medical diagnosis Risk factors |
| title | MEDICAL PROGRESS: Renal-Cell Carcinoma |
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