MEDICAL PROGRESS: Renal-Cell Carcinoma

MEDICAL PROGRESS: Renal-Cell Carcinoma

Pathologic cooperativity between renal-cancer cells of the clear-cell type and adjacent vasculature is shown in Panel A. In clear-cell renal-cell carcinoma, hypoxia-inducible factor a (HIF-α) transcription factor accumulates, resulting in the overexpression of proteins that are normally inducible wi...

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Veröffentlicht in:The New England journal of medicine 2005-12, Vol.353 (23), p.2477
Hauptverfasser: Cohen, Herbert T, McGovern, Francis J
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Genetics
Kidneys
Medical diagnosis
Risk factors
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Zusammenfassung:Pathologic cooperativity between renal-cancer cells of the clear-cell type and adjacent vasculature is shown in Panel A. In clear-cell renal-cell carcinoma, hypoxia-inducible factor a (HIF-α) transcription factor accumulates, resulting in the overexpression of proteins that are normally inducible with hypoxia, such as transforming growth factor a and β (TGF-α and TGF-β, respectively), vascular endothelial growth factor (VEGF), and platelet-derived growth factor B chain (PDGF-B).
ISSN:0028-4793
1533-4406