Genomic Diagnosis of Burkitt's Lymphoma/DRS. DAVE AND STAUDT REPLY/DR. HUMMEL AND COLLEAGUES REPLY

However, all nine Burkitt's lymphoma-discrepant cases (i.e., cases of Burkitt's lymphoma identified on the basis of gene expression but not standard diagnostic methods) were in adults. When age and clinical stage were included in the multivariate model, molecular diagnosis was not a significant independent prognostic factor for survival. The results of a univariate comparison of survival among children and adults with mBL who were treated with acute lymphoblastic leukemia (ALL)-like chemotherapy (14 children and 7 adults) or with chemotherapy regimens based on cyclophosphamide, doxorubicin, vincristine, and prednisone (2 children and 1 adult) were not meaningful, owing to the small number of cases.