The Prevention of Radiocontrast-Agent–Induced Nephropathy by Hemofiltration
Preexisting renal failure confers a risk of radiocontrast-agent–induced nephropathy after percutaneous coronary interventions. This study compared preemptive hemofiltration administered in an intensive care unit (ICU) with isotonic intravenous hydration given in a step-down unit for the prevention o...
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| Veröffentlicht in: | The New England journal of medicine 2003-10, Vol.349 (14), p.1333-1340 |
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| container_title | The New England journal of medicine |
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| creator | Marenzi, Giancarlo Marana, Ivana Lauri, Gianfranco Assanelli, Emilio Grazi, Marco Campodonico, Jeness Trabattoni, Daniela Fabbiocchi, Franco Montorsi, Piero Bartorelli, Antonio L |
| description | Preexisting renal failure confers a risk of radiocontrast-agent–induced nephropathy after percutaneous coronary interventions. This study compared preemptive hemofiltration administered in an intensive care unit (ICU) with isotonic intravenous hydration given in a step-down unit for the prevention of contrast-agent–induced nephropathy in high-risk patients. A decrease in renal function occurred less frequently with hemofiltration (in 5 percent vs. 50 percent of patients; P |
| doi_str_mv | 10.1056/NEJMoa023204 |
| format | Article |
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Preemptive hemofiltration protects renal function.
Radiocontrast-agent–induced nephropathy is a common cause of acute renal failure,
1
–
3
which can range from a transient elevation of the serum creatinine concentration to permanent renal failure necessitating dialysis. When contrast-agent–induced nephropathy complicates percutaneous coronary interventions, it is associated with significant in-hospital and long-term morbidity and mortality, as well as with a prolonged hospital stay.
1
–
8
In addition, the clinical outcome of patients who require emergency dialysis after a percutaneous coronary intervention is very poor, with a reported in-hospital mortality rate as high as 62 percent.
9
,
10
Most patients in whom contrast-agent–induced nephropathy develops have risk factors for it.
1
– . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa023204</identifier><identifier>PMID: 14523141</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Acute coronary syndromes ; Aged ; Angioplasty, Balloon, Coronary - adverse effects ; Biological and medical sciences ; Blood Urea Nitrogen ; Cardiology ; Contrast agents ; Contrast Media - adverse effects ; Coronary Angiography - adverse effects ; Female ; Hemofiltration ; Humans ; Kidney Diseases - chemically induced ; Kidney Diseases - prevention & control ; Kidney Failure, Chronic - complications ; Male ; Medical sciences ; Miscellaneous ; Mortality ; Peritoneal dialysis ; Prospective Studies ; Radiopharmaceuticals - adverse effects ; Sodium Chloride - therapeutic use ; Toxicology</subject><ispartof>The New England journal of medicine, 2003-10, Vol.349 (14), p.1333-1340</ispartof><rights>Copyright © 2003 Massachusetts Medical Society. All rights reserved.</rights><rights>2004 INIST-CNRS</rights><rights>Copyright 2003 Massachusetts Medical Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c568t-c485c3c6d0cf694590884ec858d14a1f7f160039ec5ff418b47fdaa74104bafb3</citedby><cites>FETCH-LOGICAL-c568t-c485c3c6d0cf694590884ec858d14a1f7f160039ec5ff418b47fdaa74104bafb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa023204$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa023204$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>314,776,780,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15166874$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14523141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marenzi, Giancarlo</creatorcontrib><creatorcontrib>Marana, Ivana</creatorcontrib><creatorcontrib>Lauri, Gianfranco</creatorcontrib><creatorcontrib>Assanelli, Emilio</creatorcontrib><creatorcontrib>Grazi, Marco</creatorcontrib><creatorcontrib>Campodonico, Jeness</creatorcontrib><creatorcontrib>Trabattoni, Daniela</creatorcontrib><creatorcontrib>Fabbiocchi, Franco</creatorcontrib><creatorcontrib>Montorsi, Piero</creatorcontrib><creatorcontrib>Bartorelli, Antonio L</creatorcontrib><title>The Prevention of Radiocontrast-Agent–Induced Nephropathy by Hemofiltration</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Preexisting renal failure confers a risk of radiocontrast-agent–induced nephropathy after percutaneous coronary interventions. This study compared preemptive hemofiltration administered in an intensive care unit (ICU) with isotonic intravenous hydration given in a step-down unit for the prevention of contrast-agent–induced nephropathy in high-risk patients. A decrease in renal function occurred less frequently with hemofiltration (in 5 percent vs. 50 percent of patients; P<0.001). In-hospital and cumulative one-year mortality was lower in the hemofiltration group.
Preemptive hemofiltration protects renal function.
Radiocontrast-agent–induced nephropathy is a common cause of acute renal failure,
1
–
3
which can range from a transient elevation of the serum creatinine concentration to permanent renal failure necessitating dialysis. When contrast-agent–induced nephropathy complicates percutaneous coronary interventions, it is associated with significant in-hospital and long-term morbidity and mortality, as well as with a prolonged hospital stay.
1
–
8
In addition, the clinical outcome of patients who require emergency dialysis after a percutaneous coronary intervention is very poor, with a reported in-hospital mortality rate as high as 62 percent.
9
,
10
Most patients in whom contrast-agent–induced nephropathy develops have risk factors for it.
1
– . . .</description><subject>Acute coronary syndromes</subject><subject>Aged</subject><subject>Angioplasty, Balloon, Coronary - adverse effects</subject><subject>Biological and medical sciences</subject><subject>Blood Urea Nitrogen</subject><subject>Cardiology</subject><subject>Contrast agents</subject><subject>Contrast Media - adverse effects</subject><subject>Coronary Angiography - adverse effects</subject><subject>Female</subject><subject>Hemofiltration</subject><subject>Humans</subject><subject>Kidney Diseases - chemically induced</subject><subject>Kidney Diseases - prevention & control</subject><subject>Kidney Failure, Chronic - complications</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Mortality</subject><subject>Peritoneal dialysis</subject><subject>Prospective Studies</subject><subject>Radiopharmaceuticals - adverse effects</subject><subject>Sodium Chloride - therapeutic use</subject><subject>Toxicology</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpt0E9LwzAYBvAgipvTm2cpojerSfO3xzGmm7gpMs8lTRPXsTY1aYXd_A5-Qz-JHSvMg-8lh_eX54UHgHMEbxGk7G4-fpxZCSMcQXIA-ohiHBIC2SHoQxiJkPAY98CJ9yvYDiLxMeghQiOMCOqD2WKpgxenP3VZ57YMrAleZZZbZcvaSV-Hw_d28_P1PS2zRuksmOtq6Wwl6-UmSDfBRBfW5OvWbr-fgiMj116fde8AvN2PF6NJ-PT8MB0Nn0JFmahDRQRVWLEMKsNiQmMoBNFKUJEhIpHhBjEIcawVNYYgkRJuMik5QZCk0qR4AC53uZWzH432dbKyjSvbk0kU4TjikPMW3eyQctZ7p01SubyQbpMgmGyrS_5W1_KLLrNJC53tcddVC647IL2Sa-NkqXK_dxQxJvg26GrnisInpV4V_9_7BVIagk4</recordid><startdate>20031002</startdate><enddate>20031002</enddate><creator>Marenzi, Giancarlo</creator><creator>Marana, Ivana</creator><creator>Lauri, Gianfranco</creator><creator>Assanelli, Emilio</creator><creator>Grazi, Marco</creator><creator>Campodonico, Jeness</creator><creator>Trabattoni, Daniela</creator><creator>Fabbiocchi, Franco</creator><creator>Montorsi, Piero</creator><creator>Bartorelli, Antonio L</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20031002</creationdate><title>The Prevention of Radiocontrast-Agent–Induced Nephropathy by Hemofiltration</title><author>Marenzi, Giancarlo ; Marana, Ivana ; Lauri, Gianfranco ; Assanelli, Emilio ; Grazi, Marco ; Campodonico, Jeness ; Trabattoni, Daniela ; Fabbiocchi, Franco ; Montorsi, Piero ; Bartorelli, Antonio L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c568t-c485c3c6d0cf694590884ec858d14a1f7f160039ec5ff418b47fdaa74104bafb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Acute coronary syndromes</topic><topic>Aged</topic><topic>Angioplasty, Balloon, Coronary - adverse effects</topic><topic>Biological and medical sciences</topic><topic>Blood Urea Nitrogen</topic><topic>Cardiology</topic><topic>Contrast agents</topic><topic>Contrast Media - adverse effects</topic><topic>Coronary Angiography - adverse effects</topic><topic>Female</topic><topic>Hemofiltration</topic><topic>Humans</topic><topic>Kidney Diseases - chemically induced</topic><topic>Kidney Diseases - prevention & control</topic><topic>Kidney Failure, Chronic - complications</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Mortality</topic><topic>Peritoneal dialysis</topic><topic>Prospective Studies</topic><topic>Radiopharmaceuticals - adverse effects</topic><topic>Sodium Chloride - therapeutic use</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marenzi, Giancarlo</creatorcontrib><creatorcontrib>Marana, Ivana</creatorcontrib><creatorcontrib>Lauri, Gianfranco</creatorcontrib><creatorcontrib>Assanelli, Emilio</creatorcontrib><creatorcontrib>Grazi, Marco</creatorcontrib><creatorcontrib>Campodonico, Jeness</creatorcontrib><creatorcontrib>Trabattoni, Daniela</creatorcontrib><creatorcontrib>Fabbiocchi, Franco</creatorcontrib><creatorcontrib>Montorsi, Piero</creatorcontrib><creatorcontrib>Bartorelli, Antonio L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Pharma and Biotech Premium PRO</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>eLibrary</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>New England Journal of Medicine</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marenzi, Giancarlo</au><au>Marana, Ivana</au><au>Lauri, Gianfranco</au><au>Assanelli, Emilio</au><au>Grazi, Marco</au><au>Campodonico, Jeness</au><au>Trabattoni, Daniela</au><au>Fabbiocchi, Franco</au><au>Montorsi, Piero</au><au>Bartorelli, Antonio L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Prevention of Radiocontrast-Agent–Induced Nephropathy by Hemofiltration</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>2003-10-02</date><risdate>2003</risdate><volume>349</volume><issue>14</issue><spage>1333</spage><epage>1340</epage><pages>1333-1340</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Preexisting renal failure confers a risk of radiocontrast-agent–induced nephropathy after percutaneous coronary interventions. This study compared preemptive hemofiltration administered in an intensive care unit (ICU) with isotonic intravenous hydration given in a step-down unit for the prevention of contrast-agent–induced nephropathy in high-risk patients. A decrease in renal function occurred less frequently with hemofiltration (in 5 percent vs. 50 percent of patients; P<0.001). In-hospital and cumulative one-year mortality was lower in the hemofiltration group.
Preemptive hemofiltration protects renal function.
Radiocontrast-agent–induced nephropathy is a common cause of acute renal failure,
1
–
3
which can range from a transient elevation of the serum creatinine concentration to permanent renal failure necessitating dialysis. When contrast-agent–induced nephropathy complicates percutaneous coronary interventions, it is associated with significant in-hospital and long-term morbidity and mortality, as well as with a prolonged hospital stay.
1
–
8
In addition, the clinical outcome of patients who require emergency dialysis after a percutaneous coronary intervention is very poor, with a reported in-hospital mortality rate as high as 62 percent.
9
,
10
Most patients in whom contrast-agent–induced nephropathy develops have risk factors for it.
1
– . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>14523141</pmid><doi>10.1056/NEJMoa023204</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The New England journal of medicine, 2003-10, Vol.349 (14), p.1333-1340 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; New England Journal of Medicine |
| subjects | Acute coronary syndromes Aged Angioplasty, Balloon, Coronary - adverse effects Biological and medical sciences Blood Urea Nitrogen Cardiology Contrast agents Contrast Media - adverse effects Coronary Angiography - adverse effects Female Hemofiltration Humans Kidney Diseases - chemically induced Kidney Diseases - prevention & control Kidney Failure, Chronic - complications Male Medical sciences Miscellaneous Mortality Peritoneal dialysis Prospective Studies Radiopharmaceuticals - adverse effects Sodium Chloride - therapeutic use Toxicology |
| title | The Prevention of Radiocontrast-Agent–Induced Nephropathy by Hemofiltration |
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