Platelets, Petechiae, and Preservation of the Vascular WallMechanisms of Disease

Platelets, Petechiae, and Preservation of the Vascular WallMechanisms of Disease

This review concerns functional contacts between platelets and endothelial cells, with emphasis on the maintenance of vascular integrity by proangiogenic cytokines and growth factors released by platelets. These molecules bind to receptors on the surface of endothelial cells, thereby stabilizing the...

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Veröffentlicht in:The New England journal of medicine 2008-09, Vol.359 (12), p.1261
Hauptverfasser: Nachman, Ralph L, Rafii, Shahin
Format: Artikel
Sprache:eng
Schlagworte:
Angiogenesis
Blood platelets
Bone marrow
Cell adhesion & migration
Cytokines
Diabetic retinopathy
Endothelium
Proteins
Rodents
Vascular endothelial growth factor
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Zusammenfassung:This review concerns functional contacts between platelets and endothelial cells, with emphasis on the maintenance of vascular integrity by proangiogenic cytokines and growth factors released by platelets. These molecules bind to receptors on the surface of endothelial cells, thereby stabilizing the vascular-endothelium cadherin complex.
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMra0800887