A Golgi-targeted off-on fluorescent probe for real-time monitoring of pH changes in vivo

A Golgi-targeted off-on fluorescent probe for real-time monitoring of pH changes in vivo

We present the first Golgi-targeted small-molecular pH-sensitive fluorescent probe RSG, which allows an off-on fluorescence response to Golgi acidification with high sensitivity and specificity. RSG has been successfully used for real-time monitoring of Golgi pH changes induced by drug treatment at...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2019, Vol.55 (47), p.6685-6688
Hauptverfasser: Fan, Li, Wang, Xiaodong, Ge, Jinyin, Li, Feng, Zhang, Caihong, Lin, Bo, Shuang, Shaomin, Dong, Chuan
Format: Artikel
Sprache:eng
Schlagworte:
Acidification
Fluorescent indicators
Monitoring
NMR
Nuclear magnetic resonance
Real time
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Zusammenfassung:We present the first Golgi-targeted small-molecular pH-sensitive fluorescent probe RSG, which allows an off-on fluorescence response to Golgi acidification with high sensitivity and specificity. RSG has been successfully used for real-time monitoring of Golgi pH changes induced by drug treatment at the cellular level, as well as by the LPS-mediated inflammation in vivo.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc02511a