Immune aging marker associated with periodontitis in systemic lupus erythematosus patients

Periodontitis was reported more often found in SLE patients than healthy controls, 54.3% higher than healthy 28.2%, and was estimated related to autoimmune condition. Recently, SLE associated with the immune aging, SLE patients had similarities with immune system of elderly. Expression of IL-2 and IL10 associated with immune aging as T cell, were associated with cytotoxic activity, signaling and low number of naïve T cells were known as biomarker of immune aging. Objectives: To analyze correlation between periodontitis severity with disease activity, IL-2 and IL-10 levels in SLE patients. Methods: Subjects were 61 patients with SLE; SLEDAI score 0-42 collected from Dr. Saiful Anwar General Hospital, Malang Indonesia. Periodontitis severity was measured using Periodontal Index (PI) criteria. IL-2 and IL-10 levels were measured by using ELISA. Result: Clinical manifestations of periodontitis were bleeding gum 88.3%, high calculus index 44.9% found periodontal pocket 73.8% and loose teeth 13.2% among patients. PI score patients were 2.45±0.82. There were significantly positive correlation between PI score and SLEDAI score (r:0.930; p = 0.000), with IL-2 (r: -0927; p =