Trichodysplasia spinulosa mimicking lichen nitidus in a renal transplant patient
Trichodysplasia spinulosa (TS) is a rare cutaneous condition associated with the TSPyV and characterized by skin‐colored, folliculocentric papules with keratin spicule formation. TS is seen almost exclusively in immunosuppressed individuals, often presenting in patients with a history of solid organ...
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Veröffentlicht in: | Pediatric transplantation 2019-06, Vol.23 (4), p.e13394-n/a |
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creator | Barone, Hope Brockman, Ross Johnson, Luke Al‐Uzri, Amira Wright, Mary Mengden‐Koon, Stephanie Funk, Tracy |
description | Trichodysplasia spinulosa (TS) is a rare cutaneous condition associated with the TSPyV and characterized by skin‐colored, folliculocentric papules with keratin spicule formation. TS is seen almost exclusively in immunosuppressed individuals, often presenting in patients with a history of solid organ transplantation or chemotherapy for a lymphoreticular malignancy. We report a case of widespread TS in a 9‐year‐old girl with a history of renal transplantation complicated by BK viremia, which is also caused by a polyomavirus, BKPyV. The clinical presentation of TS in this case morphologically resembled the more common, harmless skin condition known as “lichen nitidus,” and was more extensive than expected for TS, creating a diagnostic challenge. This case illustrates an important presentation of severe TS of which transplant teams, oncologists, primary care providers, and dermatologists should be aware. |
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TS is seen almost exclusively in immunosuppressed individuals, often presenting in patients with a history of solid organ transplantation or chemotherapy for a lymphoreticular malignancy. We report a case of widespread TS in a 9‐year‐old girl with a history of renal transplantation complicated by BK viremia, which is also caused by a polyomavirus, BKPyV. The clinical presentation of TS in this case morphologically resembled the more common, harmless skin condition known as “lichen nitidus,” and was more extensive than expected for TS, creating a diagnostic challenge. This case illustrates an important presentation of severe TS of which transplant teams, oncologists, primary care providers, and dermatologists should be aware.</description><identifier>ISSN: 1397-3142</identifier><identifier>EISSN: 1399-3046</identifier><identifier>DOI: 10.1111/petr.13394</identifier><identifier>PMID: 30916861</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>antibody‐mediated rejection ; BK Virus ; Case reports ; Chemotherapy ; Child ; Congenital Abnormalities - surgery ; Diagnosis, Differential ; donor‐specific antibodies ; Female ; Humans ; Immunocompromised Host ; Immunosuppressive Agents - adverse effects ; Immunosuppressive Agents - therapeutic use ; intravenous gamma globulin ; Keratin ; Keratins - chemistry ; Kidney - abnormalities ; Kidney - surgery ; Kidney Diseases - complications ; Kidney Diseases - congenital ; Kidney Diseases - surgery ; Kidney transplantation ; Kidney Transplantation - adverse effects ; Lichen Nitidus ; Malignancy ; Mimicry ; polymerase chain reaction ; Polyomavirus ; Polyomavirus Infections - therapy ; Postoperative Complications ; Skin ; Skin - pathology ; Skin diseases ; Skin Diseases - diagnosis ; Skin Diseases - etiology ; Transplants & implants ; trichodysplasia spinulosa ; trichodysplasia spinulosa‐associated polyomavirus ; Tumor Virus Infections - therapy ; Viremia</subject><ispartof>Pediatric transplantation, 2019-06, Vol.23 (4), p.e13394-n/a</ispartof><rights>2019 Wiley Periodicals, Inc.</rights><rights>2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3244-a1f2c2fd4d8a5f2ad125375d31badb68e540191e26686d25b968fd6c5a8d19e13</citedby><cites>FETCH-LOGICAL-c3244-a1f2c2fd4d8a5f2ad125375d31badb68e540191e26686d25b968fd6c5a8d19e13</cites><orcidid>0000-0002-6316-1747 ; 0000-0001-6532-7117</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpetr.13394$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpetr.13394$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30916861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Barone, Hope</creatorcontrib><creatorcontrib>Brockman, Ross</creatorcontrib><creatorcontrib>Johnson, Luke</creatorcontrib><creatorcontrib>Al‐Uzri, Amira</creatorcontrib><creatorcontrib>Wright, Mary</creatorcontrib><creatorcontrib>Mengden‐Koon, Stephanie</creatorcontrib><creatorcontrib>Funk, Tracy</creatorcontrib><title>Trichodysplasia spinulosa mimicking lichen nitidus in a renal transplant patient</title><title>Pediatric transplantation</title><addtitle>Pediatr Transplant</addtitle><description>Trichodysplasia spinulosa (TS) is a rare cutaneous condition associated with the TSPyV and characterized by skin‐colored, folliculocentric papules with keratin spicule formation. TS is seen almost exclusively in immunosuppressed individuals, often presenting in patients with a history of solid organ transplantation or chemotherapy for a lymphoreticular malignancy. We report a case of widespread TS in a 9‐year‐old girl with a history of renal transplantation complicated by BK viremia, which is also caused by a polyomavirus, BKPyV. The clinical presentation of TS in this case morphologically resembled the more common, harmless skin condition known as “lichen nitidus,” and was more extensive than expected for TS, creating a diagnostic challenge. This case illustrates an important presentation of severe TS of which transplant teams, oncologists, primary care providers, and dermatologists should be aware.</description><subject>antibody‐mediated rejection</subject><subject>BK Virus</subject><subject>Case reports</subject><subject>Chemotherapy</subject><subject>Child</subject><subject>Congenital Abnormalities - surgery</subject><subject>Diagnosis, Differential</subject><subject>donor‐specific antibodies</subject><subject>Female</subject><subject>Humans</subject><subject>Immunocompromised Host</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>intravenous gamma globulin</subject><subject>Keratin</subject><subject>Keratins - chemistry</subject><subject>Kidney - abnormalities</subject><subject>Kidney - surgery</subject><subject>Kidney Diseases - complications</subject><subject>Kidney Diseases - congenital</subject><subject>Kidney Diseases - surgery</subject><subject>Kidney transplantation</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Lichen Nitidus</subject><subject>Malignancy</subject><subject>Mimicry</subject><subject>polymerase chain reaction</subject><subject>Polyomavirus</subject><subject>Polyomavirus Infections - therapy</subject><subject>Postoperative Complications</subject><subject>Skin</subject><subject>Skin - pathology</subject><subject>Skin diseases</subject><subject>Skin Diseases - diagnosis</subject><subject>Skin Diseases - etiology</subject><subject>Transplants & implants</subject><subject>trichodysplasia spinulosa</subject><subject>trichodysplasia spinulosa‐associated polyomavirus</subject><subject>Tumor Virus Infections - therapy</subject><subject>Viremia</subject><issn>1397-3142</issn><issn>1399-3046</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF1LwzAUhoMobk5v_AES8E7o7EnSrLmUMT9g4JB5HdIm1cw2rUnL2L-3W6eXnptzLp7z8vIgdA3xFPq5b0zrp0CpYCdoDFSIiMaMnx7uWUSBkRG6CGETx8BZys7RiMYCeMphjFZrb_PPWu9CU6pgFQ6NdV1ZB4UrW9n8y7oPXPaIcdjZ1uouYOuwwt44VeLWK7f_dC1uVGuNay_RWaHKYK6Oe4LeHxfr-XO0fH16mT8so5wSxiIFBclJoZlOVVIQpYEkdJZoCpnSGU9NwmIQYAjve2qSZIKnheZ5olINwgCdoNsht_H1d2dCKzd15_tOQRJCGRGMg-ipu4HKfR2CN4VsvK2U30mI5V6e3MuTB3k9fHOM7LLK6D_011YPwABsbWl2_0TJ1WL9NoT-AFz2esY</recordid><startdate>201906</startdate><enddate>201906</enddate><creator>Barone, Hope</creator><creator>Brockman, Ross</creator><creator>Johnson, Luke</creator><creator>Al‐Uzri, Amira</creator><creator>Wright, Mary</creator><creator>Mengden‐Koon, Stephanie</creator><creator>Funk, Tracy</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><orcidid>https://orcid.org/0000-0002-6316-1747</orcidid><orcidid>https://orcid.org/0000-0001-6532-7117</orcidid></search><sort><creationdate>201906</creationdate><title>Trichodysplasia spinulosa mimicking lichen nitidus in a renal transplant patient</title><author>Barone, Hope ; Brockman, Ross ; Johnson, Luke ; Al‐Uzri, Amira ; Wright, Mary ; Mengden‐Koon, Stephanie ; Funk, Tracy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3244-a1f2c2fd4d8a5f2ad125375d31badb68e540191e26686d25b968fd6c5a8d19e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>antibody‐mediated rejection</topic><topic>BK Virus</topic><topic>Case reports</topic><topic>Chemotherapy</topic><topic>Child</topic><topic>Congenital Abnormalities - surgery</topic><topic>Diagnosis, Differential</topic><topic>donor‐specific antibodies</topic><topic>Female</topic><topic>Humans</topic><topic>Immunocompromised Host</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>intravenous gamma globulin</topic><topic>Keratin</topic><topic>Keratins - chemistry</topic><topic>Kidney - abnormalities</topic><topic>Kidney - surgery</topic><topic>Kidney Diseases - complications</topic><topic>Kidney Diseases - congenital</topic><topic>Kidney Diseases - surgery</topic><topic>Kidney transplantation</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Lichen Nitidus</topic><topic>Malignancy</topic><topic>Mimicry</topic><topic>polymerase chain reaction</topic><topic>Polyomavirus</topic><topic>Polyomavirus Infections - therapy</topic><topic>Postoperative Complications</topic><topic>Skin</topic><topic>Skin - pathology</topic><topic>Skin diseases</topic><topic>Skin Diseases - diagnosis</topic><topic>Skin Diseases - etiology</topic><topic>Transplants & implants</topic><topic>trichodysplasia spinulosa</topic><topic>trichodysplasia spinulosa‐associated polyomavirus</topic><topic>Tumor Virus Infections - therapy</topic><topic>Viremia</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barone, Hope</creatorcontrib><creatorcontrib>Brockman, Ross</creatorcontrib><creatorcontrib>Johnson, Luke</creatorcontrib><creatorcontrib>Al‐Uzri, Amira</creatorcontrib><creatorcontrib>Wright, Mary</creatorcontrib><creatorcontrib>Mengden‐Koon, Stephanie</creatorcontrib><creatorcontrib>Funk, Tracy</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Pediatric transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barone, Hope</au><au>Brockman, Ross</au><au>Johnson, Luke</au><au>Al‐Uzri, Amira</au><au>Wright, Mary</au><au>Mengden‐Koon, Stephanie</au><au>Funk, Tracy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trichodysplasia spinulosa mimicking lichen nitidus in a renal transplant patient</atitle><jtitle>Pediatric transplantation</jtitle><addtitle>Pediatr Transplant</addtitle><date>2019-06</date><risdate>2019</risdate><volume>23</volume><issue>4</issue><spage>e13394</spage><epage>n/a</epage><pages>e13394-n/a</pages><issn>1397-3142</issn><eissn>1399-3046</eissn><abstract>Trichodysplasia spinulosa (TS) is a rare cutaneous condition associated with the TSPyV and characterized by skin‐colored, folliculocentric papules with keratin spicule formation. TS is seen almost exclusively in immunosuppressed individuals, often presenting in patients with a history of solid organ transplantation or chemotherapy for a lymphoreticular malignancy. We report a case of widespread TS in a 9‐year‐old girl with a history of renal transplantation complicated by BK viremia, which is also caused by a polyomavirus, BKPyV. The clinical presentation of TS in this case morphologically resembled the more common, harmless skin condition known as “lichen nitidus,” and was more extensive than expected for TS, creating a diagnostic challenge. This case illustrates an important presentation of severe TS of which transplant teams, oncologists, primary care providers, and dermatologists should be aware.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30916861</pmid><doi>10.1111/petr.13394</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-6316-1747</orcidid><orcidid>https://orcid.org/0000-0001-6532-7117</orcidid></addata></record> |
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subjects | antibody‐mediated rejection BK Virus Case reports Chemotherapy Child Congenital Abnormalities - surgery Diagnosis, Differential donor‐specific antibodies Female Humans Immunocompromised Host Immunosuppressive Agents - adverse effects Immunosuppressive Agents - therapeutic use intravenous gamma globulin Keratin Keratins - chemistry Kidney - abnormalities Kidney - surgery Kidney Diseases - complications Kidney Diseases - congenital Kidney Diseases - surgery Kidney transplantation Kidney Transplantation - adverse effects Lichen Nitidus Malignancy Mimicry polymerase chain reaction Polyomavirus Polyomavirus Infections - therapy Postoperative Complications Skin Skin - pathology Skin diseases Skin Diseases - diagnosis Skin Diseases - etiology Transplants & implants trichodysplasia spinulosa trichodysplasia spinulosa‐associated polyomavirus Tumor Virus Infections - therapy Viremia |
title | Trichodysplasia spinulosa mimicking lichen nitidus in a renal transplant patient |
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