Comparative Activity of Piperacillin/Tazobactam against Clinical Isolates of Extended- Spectrum [beta]-Lactamase-Producing Enterobacteriaceae

Comparative Activity of Piperacillin/Tazobactam against Clinical Isolates of Extended- Spectrum [beta]-Lactamase-Producing Enterobacteriaceae

[beta]-Lactam resistance on the part of the Enterobacteriaceae causes serious therapeutic problems in our institutions due to their production of extended-spectrum [beta]-lactamases (ES[beta]Ls). We studied the in vitro activity of [beta]-lactam/[beta]-lactamase inhibitor combinations and third-gene...

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Veröffentlicht in:Chemotherapy (Basel) 1998-11, Vol.44 (6), p.377
Hauptverfasser: Pagani, Laura, Migliavacca, Roberta, Luzzaro, Francesco, Giacobone, Ernesto, Perilli, Mariagrazia, Micheletti, Piero, Amicosante, Gianfranco
Format: Artikel
Sprache:eng
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Zusammenfassung:[beta]-Lactam resistance on the part of the Enterobacteriaceae causes serious therapeutic problems in our institutions due to their production of extended-spectrum [beta]-lactamases (ES[beta]Ls). We studied the in vitro activity of [beta]-lactam/[beta]-lactamase inhibitor combinations and third-generation cephalosporins and monobactams against 71 clinically relevant Enterobacteriaceae which produced TEM- and SHV-derivative ES[beta]Ls. Of the single drugs and combinations tested, piperacillin/tazobactam proved to be the most effective. Piperacillin/tazobactam was highly active against
ISSN:0009-3157
1421-9794