Nondipping and Its Relation to Glomerulopathy and Hyperfiltration in Adolescents With Type 1 Diabetes

Nondipping and Its Relation to Glomerulopathy and Hyperfiltration in Adolescents With Type 1 Diabetes Torun B. Torbjörnsdotter , MD 1 , Georg A. Jaremko , MD, PHD 2 and Ulla B. Berg , MD, PHD 1 1 Department of Pediatrics, Karolinska Institutet, Huddinge University Hospital, Stockholm, Sweden 2 Department of Pathology, Karolinska Institutet, Karolinska Hospital, Stockholm, Sweden Address correspondence and reprint requests to T. Torbjörnsdotter, MD, Department of Pediatrics, Karolinska Institutet, Huddinge University Hospital, S-14186 Stockholm, Sweden. E-mail: torun.torbjornsdotter{at}klinvet.ki.se Abstract OBJECTIVE —To determine whether there is a relation between dipping/nondipping status and end-organ damage (measured as renal glomerulopathy) and long-term renal function in order to predict the development of nephropathy in normoalbuminuric patients with type 1 diabetes. RESEARCH DESIGN AND METHODS —Analysis of renal biopsy and ambulatory blood pressure measurements was done in relation to renal function tests performed during a 10-year period. Forty unselected patients (16 girls), with a mean age of 17.7 years and a mean duration of 10.7 years, were studied. The renal biopsies were examined by electron microscopy. Ambulatory blood pressure was monitored (Space Labs 90 207). Systolic nondippers were defined as a