High Incidence of Type 2 Diabetes in Peroxisome Proliferator-Activated Receptor [gamma]2 Pro 1 2Ala Carriers Exposed to a High Chronic Intake of Trans Fatty Acids and Saturated Fatty Acids

One of the most frequent polymorphisms of peroxisome proliferator-activated receptor is the Ala allele. Its incidence in the expression of obesity, insulin resistance, and type 2 diabetes is controversial. Pisabarro et al hypothesize that when exposed to a chronic environment of high trans fatty acid (FA) and saturated FA intake and sedentary lifestyle, 12Ala carriers express more type 2 diabetes at lower BMI and age than subjects without the polymorphism. This could be due to some weakness in the defenses against the ectopic storage of triglycerides, particularly in myocytes and beta-cells. Here, they aim at examining these possible relationships.