The Relationship of Lipoprotein Lipase Activity and LDL size Is Dependent on Glucose Metabolism in an Elderly Population

Bos et al investigate the relationship of lipoprotein lipase (LPL) and hepatic lipase activities and cholesterol ester transfer protein mass with LDL size in 462 subjects with normal and impaired glucose metabolism or type 2 diabetes. After a thorough investigation, they conclude that high triglyceride concentration and low LPL activity are determinants of small LDL size, especially in individuals with abnormal glucose metabolism. Their findings suggest that, beyond triglyceride concentration, activities of lipolytic proteins explain the differences in LDL size in diabetic and nondiabetic people.