Antihypertensive Medications and the Risk of Incident Type 2 Diabetes: Response to Taylor et al./Antihypertensive Medications and the Risk of Incident Type 2 Diabetes: Response to Gosmanov et al

The Nurse's Health Study (NHS) I (2) suggests a protective effect for ACE inhibitors, since the risk of diabetes is higher for patients on thiazides, β-blockers, "other" antihypertensives, and CCBs. The lack of prospective clinical trials evaluating the incidence of diabetes as a primary end point and the absence of placebo-controlled studies leaves physicians wondering whether a particular antihypertensive medication causes or prevents diabetes.